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The effect of duodenal content is stronger than gastric juice.It may play an important role in tumourgenesis of gastroesophageal reflux disease. 结论：胃液及十二指肠内容物反流可通过改变抑癌基因的蛋白表达而影响致癌剂甲基戊基亚硝胺诱发大鼠食管肿瘤的作用，其中十二指肠内容物的作用较胃液更强。