tirapazamine

基本解释

Antitumor agent tirapazamine was synthesized from o-nitroaniline by oxidation to give benzofuroxanwhich reacted with sodium cyanamide followed by acid hydrolysis with an overall yield of 75%.
邻硝基苯胺经氧化得到苯并呋咱1-氧化物,与氰氨基钠反应后酸解得到抗癌剂替拉扎明,总收率75%25。
Keywords 1-Phosphatidylinositol 3-kinase inhlbitor;Uterine cervical cancer cell;Tirapazamine;in vitro inhibition;
磷脂酰肌醇-3激酶抑制剂;宫颈癌细胞;替拉扎明;体外抑制作用;
Antitumor agent tirapazamine was synthesized from o-nitroaniline by oxidation to give benzofuroxanwhich reacted with sodium cyanamide followed by acid hydrolysis with an overall yield of 75%。
邻硝基苯胺经氧化得到苯并呋咱1-氧化物,与氰氨基钠反应后酸解得到抗癌剂替拉扎明,总收率75%25。