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Substance P(SP)、calcitonin gene - related peptide(CGRP) and nitric oxide (NO) may be involved in the transmission of pulpalgia and facial inflammatory pain. 疼痛是牙体硬组织和牙髓疾患中常见的症状，也是对活髓牙进行牙体、牙髓治疗操作时令患者恐惧的症状。